Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

Taku Fukuzawa, Zenjiro Sampei, Kenta Haraya, +31

Scientific Reports

ImmunohematologyImmunologyBlood CellPathologyComplement Activity +15

Engineered Monoclonal Antibody with Novel Antigen-Sweeping Activity In Vivo

Tomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, +11

PLoS ONE

Immunocytochemical TechniqueEngineeringImmunoengineeringImmunologyConventional Antibody +12

HNF4α is a Crucial Modulator of the Cholesterol-Dependent Regulation of NPC1L1

Yuki Iwayanagi, Tappei Takada, Hiroshi Suzuki

Pharmaceutical Research

Molecular PhysiologySignal TransductionBiochemistryOxysterolCholesterol-dependent Regulation +5

Cynomolgus monkey model of interleukin‐31‐induced scratching depicts blockade of human interleukin‐31 receptor A by a humanized monoclonal antibody

Sohei Oyama, Hidetomo Kitamura, Taichi Kuramochi, +16

Experimental Dermatology

LXR Alpha Transactivates Mouse Organic Solute Transporter Alpha and Beta via IR-1 Elements Shared with FXR

Masae Okuwaki, Tappei Takada, Yuki Iwayanagi, +4

Pharmaceutical Research

Molecular PharmacologyMolecular PhysiologySignal TransductionBiochemistryMedicine +4

Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering

Yuki Iwayanagi, Tomoyuki Igawa, Atsuhiko Maeda, +12

The Journal of Immunology

Human NPC1L1 Expression is Positively Regulated by PPARα

Yuki Iwayanagi, Tappei Takada, Fumiya Tomura, +4

Pharmaceutical Research

Transcriptional RegulationSignal TransductionSignaling PathwayMolecular RegulationHuman Npc1l1 Expression +4

MHC-associated peptide proteomics enabling highly sensitive detection of immunogenic sequences for the development of therapeutic antibodies with low immunogenicity

Nobuo Sekiguchi, Chiyomi Kubo, Ayako Takahashi, +12

mAbs

EngineeringImmunologyPathologyAntigen ProcessingImmunotherapy +19

Calcium-dependent antigen binding as a novel modality for antibody recycling by endosomal antigen dissociation

Naoka Hironiwa, Shinya Ishii, Shojiro Kadono, +5

mAbs

Immunocytochemical TechniqueImmunologyImmunodominanceMolecular BiologyAntigen Dissociation +17

Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody

Atsuhiko Maeda, Yuki Iwayanagi, Kenta Haraya, +6

mAbs

Enhanced Fcrn BindingHuman Igg1 VariantImmunologyPathologyImmunotherapy +17