Tsukasa Sanada

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).

Yumiko Shibouta, Yasuhiro Inada, M Ojima et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 213 citations

Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor

Mami Ojima, Yoshiyuki Inada, Yumiko Shibouta et al. · European Journal of Pharmacology · 1997 · 141 citations

Molecular Pharmacology, Angiotensin At1 Receptor, Molecular Physiology +9

Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (+-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylate (TCV-116), in various hypertensive rats.

Yasuhiro Inada, Takeo Wada, Yumiko Shibouta et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 72 citations

Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone

Takeo Wada, Yoshiyuki Inada, Tsukasa Sanada et al. · European Journal of Pharmacology · 1994 · 29 citations

Molecular Pharmacology, Hypertension, Medicine +8

Combined Effects of the Angiotensin II Antagonist Candesartan Cilexetil(TCV-116) and Other Classes of Antihypertensive Drugs in Spontaneously Hypertensive Rats.

Takeo Wada, Tsukasa Sanada, Mami Ojima et al. · Hypertension Research · 1996 · 16 citations · Full text