Nicole C. Thomas - Concepedia

Author

Nicole C. Thomas

Mirati Therapeutics (United States)ORCID

Also Known As

N, Thomas, N.C. Thomas, Nicole C. Thomas, Nicole Thomas

Publications

1.6K

Citations

H-Index

Concepts

All Affiliations

Mirati Therapeutics (United States)University of Wisconsin–Madison Pfizer (United States)

About

Nicole C. Thomas is an author at Mirati Therapeutics (United States) specializing in medicine, crystallography, and structural biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	2	2	488
2	Natural Sciences	1	1	23
3	Biochemistry	1	1	23
4	Molecular Biology	1	1	23
5	Pharmacology	1	1	465

Nicole C. Thomas

Publications

1.5K

Citations

H-Index

Page 1

	Year	Citations
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS <sup>G12D</sup> Inhibitor Xiaolun Wang, Shelley Allen, James F. Blake, Journal of Medicinal Chemistry	2021	644
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor Jill Hallin, Vickie Bowcut, Andrew Calinisan, Nature Medicine MedicinePharmacologyPharmacotherapyAnti-tumor EfficacyAnti-cancer Agent	2022	465
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of <i>MTAP</i> -Deleted Cancers Christopher R. Smith, Ruth Aranda, Thomas P. Bobinski, Journal of Medicinal Chemistry	2022	139
Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold James W. Checco, Dale F. Kreitler, Nicole C. Thomas, Proceedings of the National Academy of Sciences	2015	112
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction John M. Ketcham, Jacob R. Haling, Shilpi Khare, Journal of Medicinal Chemistry	2022	87
Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif Zvi Hayouka, Nicole C. Thomas, D.E. Mortenson, Journal of the American Chemical Society Magainin 2Crystal StructurePeptide EngineeringMolecular BiologyPhenylalanine Zipper	2015	23
Evaluation of β‐Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure D.E. Mortenson, Dale F. Kreitler, Nicole C. Thomas, ChemBioChem	2017	20
Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors Christopher R. Smith, Ruth Aranda, James G. Christensen, Bioorganic & Medicinal Chemistry	2022	14
Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits Christopher R. Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, RSC Medicinal Chemistry	2022	12

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