Robert S. Mittler

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

Ignacio Melero, Walter W. Shuford, S A Newby et al. · Nature Medicine · 1997 · 883 citations

Tumor Immunology, Cancer Immunosurveillance, T-regulatory Cell +8

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

Walter W. Shuford, Kerry Klussman, Douglas D. Tritchler et al. · The Journal of Experimental Medicine · 1997 · 787 citations · Full text

Adaptive Immune System, T-regulatory Cell, Immunology +17

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

Peter S. Linsley, Jeff Bradshaw, JoAnne L. Greene et al. · Immunity · 1996 · 590 citations · Full text

Signal Transduction, Cell Signaling, Cell Trafficking +9

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

Chikara Takahashi, Robert S. Mittler, Anthony T. Vella · The Journal of Immunology · 1999 · 378 citations · Full text

Adaptive Immune System, T-regulatory Cell, Immunology +19

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

Ignacio Melero, Janet Johnston, Walter W. Shufford et al. · Cellular Immunology · 1998 · 356 citations

Anti-4-1bb Monoclonal Antibodies, Cancer Immunosurveillance, Immunology +8