Gerhard Hannig

Strategies for optimizing heterologous protein expression in Escherichia coli

Gerhard Hannig, Savvas C. Makrides · Trends in biotechnology · 1998 · 489 citations

Life Sciences, Biotechnology, Molecular Biology +14

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

Joel Castro, Andrea M. Harrington, Patrick A. Hughes et al. · Gastroenterology · 2013 · 294 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Robert Busby, Alexander P. Bryant, Wilmin Bartolini et al. · European Journal of Pharmacology · 2010 · 248 citations

Life Sciences, Pharmacology, Physiology +13

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

Alexander P. Bryant, Robert Busby, Wilmin Bartolini et al. · Life Sciences · 2010 · 224 citations

Medicine, Pharmacology, Gastroenterology +9

Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation

Robert Busby, Marco M. Kessler, Wilmin Bartolini et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 136 citations

Medicine, Pharmacokinetics, Pharmacology +17