Wilmin Bartolini

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Robert Busby, Alexander P. Bryant, Wilmin Bartolini et al. · European Journal of Pharmacology · 2010 · 248 citations

Life Sciences, Pharmacology, Physiology +13

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

Alexander P. Bryant, Robert Busby, Wilmin Bartolini et al. · Life Sciences · 2010 · 224 citations

Medicine, Pharmacology, Gastroenterology +9

Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation

Robert Busby, Marco M. Kessler, Wilmin Bartolini et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 136 citations

Medicine, Pharmacokinetics, Pharmacology +17

Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System

Lin Chang, Brian E. Lacy, Baha Moshiree et al. · The American Journal of Gastroenterology · 2021 · 70 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Randomized Trial of 2 Delayed-Release Formulations of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

William D. Chey, Gregory S. Sayuk, Wilmin Bartolini et al. · The American Journal of Gastroenterology · 2020 · 55 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17