Concepedia

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Robert Busby, Alexander P. Bryant, Wilmin Bartolini, Etchell A. Cordero, Gerhard Hannig, Marco M. Kessler, Shalina Mahajan‐Miklos, Christine M. Pierce, Robert Solinga, Li Jing Sun,

European Journal of Pharmacology · 2010 · 248 citations · 34 references

DOI

Concepts

References

34

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

Guanylyl cyclase is a heat-stable enterotoxin receptor

Stephanie Schulz, Cecelia K. Green, Peter S.T. Yuen et al. · Cell · 1990 · 608 citations

, , +9

Guanylin: an endogenous activator of intestinal guanylate cyclase.

Mark G. Currie, Kam F. Fok, Jun Kato et al. · Proceedings of the National Academy of Sciences · 1992 · 582 citations

, , +13

Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.

F. K. Hamra, Leonard R. Forte, Sammy L. Eber et al. · Proceedings of the National Academy of Sciences · 1993 · 340 citations

, , +8

13C NMR chemical shifts can predict disulfide bond formation

Deepak Sharma, Krishna Rajarathnam · Journal of Biomolecular NMR · 2000 · 298 citations

, , +11