Concepedia

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

Alexander P. Bryant, Robert Busby, Wilmin Bartolini, Etchell A. Cordero, Gerhard Hannig, Marco M. Kessler, Christine M. Pierce, Robert Solinga, Jenny Tobin, Shalina Mahajan‐Miklos,

Life Sciences · 2010 · 224 citations · 23 references

DOI

Concepts

References

23

Guanylyl cyclase is a heat-stable enterotoxin receptor

Stephanie Schulz, Cecelia K. Green, Peter S.T. Yuen et al. · Cell · 1990 · 608 citations

, , +9

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

Alexander Pfeifer, Attila Aszódi, Ursula Seidler et al. · Science · 1996 · 409 citations

, , +16

A functional CFTR protein is required for mouse intestinal cAMP‐, cGMP‐ and Ca<sup>2+</sup>‐dependent HCO<sub>3</sub><sup>−</sup> secretion

Ursula Seidler, Irina Blumenstein, Alexandra Kretz et al. · The Journal of Physiology · 1997 · 259 citations · Full text

, , +17

Bowel habits in young adults not seeking health care

Robert S. Sandler, Douglas A. Drossman · Digestive Diseases and Sciences · 1987 · 241 citations

, , +6

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

Hélène Eutamène, Sylvie Bradesi, Muriel Larauche et al. · Neurogastroenterology & Motility · 2009 · 186 citations

, , +17