Concepedia

Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation

Robert Busby, Marco M. Kessler, Wilmin Bartolini, Alexander P. Bryant, Gerhard Hannig, Carolyn S. Higgins, Robert Solinga, Jenny Tobin, James Wakefield, Caroline B. Kurtz,

Journal of Pharmacology and Experimental Therapeutics · 2012 · 136 citations · 34 references

References

34

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

Mark A. Bradford · Analytical Biochemistry · 1976 · 225.4K citations

Life Sciences, Biochemistry, Protein Biochemistry +7

Guanylyl cyclase is a heat-stable enterotoxin receptor

Stephanie Schulz, Cecelia K. Green, Peter S.T. Yuen et al. · Cell · 1990 · 608 citations

Life Sciences, Biochemistry, Molecular Biology +9

Guanylin: an endogenous activator of intestinal guanylate cyclase.

Mark G. Currie, Kam F. Fok, Jun Kato et al. · Proceedings of the National Academy of Sciences · 1992 · 582 citations

Life Sciences, Biochemistry, Molecular Biology +13

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

William D. Chey, Anthony Lembo, Bernard J. Lavins et al. · The American Journal of Gastroenterology · 2012 · 451 citations

Medicine, Pharmacology, Pharmacotherapy +15

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

Satish S.C. Rao, Anthony Lembo, Steven J. Shiff et al. · The American Journal of Gastroenterology · 2012 · 377 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16