Caroline B. Kurtz

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

William D. Chey, Anthony Lembo, Bernard J. Lavins et al. · The American Journal of Gastroenterology · 2012 · 451 citations

Medicine, Pharmacology, Pharmacotherapy +15

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

Satish S.C. Rao, Anthony Lembo, Steven J. Shiff et al. · The American Journal of Gastroenterology · 2012 · 377 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Two Randomized Trials of Linaclotide for Chronic Constipation

Anthony Lembo, Harvey Schneier, Steven J. Shiff et al. · New England Journal of Medicine · 2011 · 372 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

Joel Castro, Andrea M. Harrington, Patrick A. Hughes et al. · Gastroenterology · 2013 · 294 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Robert Busby, Alexander P. Bryant, Wilmin Bartolini et al. · European Journal of Pharmacology · 2010 · 248 citations

Life Sciences, Pharmacology, Physiology +13