Concepedia

Two Randomized Trials of Linaclotide for Chronic Constipation

Anthony Lembo, Harvey Schneier, Steven J. Shiff, Caroline B. Kurtz, James E. MacDougall, Xinwei D. Jia, James Shao, Bernard J. Lavins, Mark G. Currie, Donald A. Fitch,

New England Journal of Medicine · 2011 · 364 citations · 14 references

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Abstract

In these two 12-week trials, linaclotide significantly reduced bowel and abdominal symptoms in patients with chronic constipation. Additional studies are needed to evaluate the potential long-term risks and benefits of linaclotide in chronic constipation. (Funded by Ironwood Pharmaceuticals and Forest Research Institute; ClinicalTrials.gov numbers, NCT00765882 and NCT00730015.).

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