Wen‐Ning Zhao

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Aravind Subramanian, Rajiv Narayan, Steven M. Corsello et al. · Cell · 2017 · 3.5K citations · Full text

Network Science, Engineering, Data Science +12

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Lisa A. Marcaurelle, Eamon Comer, Sivaraman Dandapani et al. · Journal of the American Chemical Society · 2010 · 212 citations · Full text

Combinatorial Chemistry, Aldol-based Build/couple/pair, Stereochemical Dependencies +19

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis

Brian T. D. Tobe, Andrew Crain, Alicia M. Winquist et al. · Proceedings of the National Academy of Sciences · 2017 · 151 citations · Full text

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

Frederick A. Schroeder, Michael C. Lewis, Daniel M. Fass et al. · PLoS ONE · 2013 · 137 citations · Full text

Epigenetic Change, Psychopharmacology, Epigenetics +20

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

Daniel M. Fass, Surya A. Reis, Balaram Ghosh et al. · Neuropharmacology · 2012 · 103 citations · Full text

Histone Modifications, Chromatin, Novel Cognitive Enhancer +12