An epigenetic blockade of cognitive functions in the neurodegenerating brain

Johannes Gräff, Damien Rei, Ji‐Song Guan, +13

Nature

NeuropsychologyCognitive ScienceBrain FunctionCognitive FunctionsMedicine +9

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

Mark Kilgore, Courtney A. Miller, Daniel M. Fass, +4

Neuropsychopharmacology

Alzheimer's DiseaseChromatin RemodelingMemory LossDementiaMemory +8

Phosphorylation of CBP Mediates Transcriptional Activation by Neural Activity and CaM Kinase IV

Soren Impey, Amy L. Fong, Yanhong Wang, +7

Neuron

Transcriptional RegulationSignal TransductionMolecular NeuroscienceSignaling PathwayCam Kinase Iv +8

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Lisa A. Marcaurelle, Eamon Comer, Sivaraman Dandapani, +23

Journal of the American Chemical Society

Combinatorial ChemistryAldol-based Build/couple/pairStereochemical DependenciesOrganic ChemistryPeptide Science +17

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

Jon M. Madison, Fangjian Zhou, Aparna Nigam, +22

Molecular Psychiatry

Mrna Expression AbnormalitiesEmbryonic Stem CellInduced Pluripotent Stem CellDevelopmental BiologyMedicine +10

Recruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation

Jean‐René Cardinaux, John C. Notis, Qinghong Zhang, +5

Molecular and Cellular Biology

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder

Sabine Bavamian, Nikolaos Mellios, Jasmin Lalonde, +10

Molecular Psychiatry

PsychiatryMedicineGeneticsPsychiatric GeneticsNon-coding Rna +8

Calcium and cAMP Signals Differentially Regulate cAMP-responsive Element-binding Protein Function via a Rap1-Extracellular Signal-regulated Kinase Pathway

Savraj Grewal, Daniel M. Fass, Hong Yao, +3

Journal of Biological Chemistry

Molecular RegulationMolecular BiologyCamp SignalingCellular PhysiologySignaling Pathway +15

Deacetylase Activity Is Required for cAMP Activation of a Subset of CREB Target Genes

Daniel M. Fass, Jennifer E.F. Butler, Richard H. Goodman

Journal of Biological Chemistry

Histone ModificationsMolecular RegulationGeneticsDeacetylase ActivityMolecular Biology +23

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

Frederick A. Schroeder, Michael C. Lewis, Daniel M. Fass, +14

PLoS ONE

Epigenetic ChangePsychopharmacologyEpigeneticsSocial SciencesHdac Inhibition +18