Nicola Neretti

L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco, Takahiro Ito, Anna P. Petrashen et al. · Nature · 2019 · 1.2K citations

Inflammation, Cytokine, Immunology +8

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

Matthew Simon, Michael Van Meter, Julia Ablaeva et al. · Cell Metabolism · 2019 · 473 citations · Full text

Inflammation, Lifespan Extension, Autoimmune Disease +11

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

Marco De Cecco, Steven W. Criscione, Edward Peckham et al. · Aging Cell · 2013 · 460 citations · Full text

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

Marco De Cecco, Steven W. Criscione, Abigail L. Peterson et al. · Aging · 2013 · 380 citations · Full text

Knockout Mouse, Chromatin, Transgenerational Effect +15

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

Mikołaj Ogrodnik, Shane A. Evans, Edward Fielder et al. · Aging Cell · 2021 · 371 citations · Full text