Ryan J. Quinton

Whole-genome doubling confers unique genetic vulnerabilities on tumour cells

Ryan J. Quinton, Amanda DiDomizio, Marc A. Vittoria et al. · Nature · 2021 · 254 citations · Full text

Genome Instability, Tumor Heterogeneity, Genetics +3

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

Wenjian Gan, Xiaoming Dai, Xiangpeng Dai et al. · Nature Cell Biology · 2020 · 92 citations · Full text

Signal Transduction, Developmental Biology, Signaling Pathway +12

Nuclear envelope rupture drives genome instability in cancer

Sanghee Lim, Ryan J. Quinton, Neil J. Ganem · Molecular Biology of the Cell · 2016 · 59 citations · Full text

Chromatin, Genome Instability, Rupture Events +15

Identification of the kinase STK25 as an upstream activator of LATS signaling

Sanghee Lim, Nicole Hermance, Tenny Mudianto et al. · Nature Communications · 2019 · 59 citations · Full text

Hippo Signaling, Hippo Activation Distinct, Cancer Biology +20

A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation

Marc A. Vittoria, Elizabeth M. Shenk, Kevin P. O’Rourke et al. · Molecular Biology of the Cell · 2018 · 19 citations · Full text

Tetraploid Cell Proliferation, Single Mirna, Cancer Biology +19