Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

Yang Gao, Naoe Taira Nihira, Xia Bu, +24

Nature Cell Biology

Anti-pd-1 ImmunotherapyCancer ImmunosurveillanceImmunologyTumor ImmunityPd-l1 Nuclear Translocation +8

Single tumor-initiating cells evade immune clearance by recruiting type II macrophages

Xiaocan Guo, Yang Zhao, Huan Yan, +14

Genes & Development

Immune ClearanceImmunologyImmunoeditingImmunologic MechanismImmune System +16

Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

Xiaoming Dai, Xia Bu, Yang Gao, +14

Molecular Cell

Cancer ImmunosurveillanceMedicineImmunologyTumor ImmunityImmune Checkpoint Inhibitor +8

Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

Jianping Guo, Ji Cheng, Nana Zheng, +10

Advanced Science

Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis

Xiaoming Dai, Peilu She, Fangtao Chi, +9

Journal of Biological Chemistry

Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1

Yuan Si, Xinyan Ji, Xiaolei Cao, +16

Cancer Research

Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1

Tao Zhang, Daichao Xu, Elijah Trefts, +37

Science

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

Wenjian Gan, Xiaoming Dai, Xiangpeng Dai, +18

Nature Cell Biology

Signal TransductionDevelopmental BiologySignaling PathwayCell RegulationMedicine +10

Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling

Ruihong Yuan, Xiaoming Dai, Yisong Li, +2

Molecular Medicine Reports

Extracellular MicrovesiclesMir‑29a‑modified Hadsc ExosomesDermatologyTgf-β2/smad3 SignalingExcessive Scar Formation +21

YAP activates the Hippo pathway in a negative feedback loop

Xiaoming Dai, Huan Liu, Shuying Shen, +7

Cell Research

Molecular PhysiologySignal TransductionPhysiologyNegative Feedback LoopCentral Nervous System +6