Xiangpeng Dai

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

Jinfang Zhang, Xia Bu, Haizhen Wang et al. · Nature · 2017 · 1K citations · Full text

Tumor Biology, Cancer Immune Surveillance, Cancer Immunosurveillance +12

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

Xiangpeng Dai, Wenjian Gan, Xiaoning Li et al. · Nature Medicine · 2017 · 333 citations · Full text

Molecular Biology, Bet Inhibitors, Spop Mutations +6

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

Wenjian Gan, Xiangpeng Dai, Andrea Lunardi et al. · Molecular Cell · 2015 · 216 citations · Full text

Spop Promotes Ubiquitination, Urology, Signal Transduction +11

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

Lixin Wan, Kexin Xu, Yongkun Wei et al. · Molecular Cell · 2018 · 192 citations · Full text

Oncogenic Function, Signal Transduction, Signaling Pathway +11

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

Bin Wang, Zuliang Jie, Donghyun Joo et al. · Nature · 2017 · 186 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7