Kevin P. O’Rourke

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Caroline A. Lindemans, Marco Calafiore, Anna Mertelsmann et al. · Nature · 2015 · 1.1K citations · Full text

Inflammation, Cytokine, Mucosal Immunology +7

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

Lukas E. Dow, Kevin P. O’Rourke, Janelle Simon et al. · Cell · 2015 · 548 citations · Full text

Tumor Biology, Cell Regulation, Medicine +8

A rectal cancer organoid platform to study individual responses to chemoradiation

Karuna Ganesh, Chao Wu, Kevin P. O’Rourke et al. · Nature Medicine · 2019 · 546 citations · Full text

Radiation Therapy, Gastrointestinal Oncology, Medicine +8

Inducible in vivo genome editing with CRISPR-Cas9

Lukas E. Dow, Jonathan Fisher, Kevin P. O’Rourke et al. · Nature Biotechnology · 2015 · 499 citations · Full text

Vivo Genome, In Vivo Gene Therapy, Natural Sciences +7

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

Neil J. Ganem, Hauke Cornils, Shang-Yi Chiu et al. · Cell · 2014 · 366 citations · Full text

Inflammation, Cytokine, Immune Checkpoint Inhibitor +5