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Cell

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Cell

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Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Marcus Ruscetti, John P. Morris, Riccardo Mezzadra, +17

Cell

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Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

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Nature Biotechnology

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Granule exocytosis mediates immune surveillance of senescent cells

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Oncogene

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

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Proceedings of the National Academy of Sciences

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Senescence of Activated Stellate Cells Limits Liver Fibrosis

Valery Krizhanovsky, Monica Yon, Ross A. Dickins, +6

Cell

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Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

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Nature Biotechnology

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MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis

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Nature Cancer

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

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Nature Cancer

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