Wayne D. Klohs

2-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

S. KLUTCHKO, James M. Hamby, Diane H. Boschelli et al. · Journal of Medicinal Chemistry · 1998 · 130 citations · Full text

Anti-Angiogenic Activity of Selected Receptor Tyrosine Kinase Inhibitors, PD166285 and PD173074: Implications for Combination Treatment with Photodynamic Therapy

Charles J. Dimitroff, Wayne D. Klohs, Amarnath Sharma et al. · Investigational New Drugs · 1999 · 96 citations

Anti-angiogenic Activity, Angiogenesis, Photodynamic Therapy +11

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Diane H. Boschelli, Zhipei Wu, S. KLUTCHKO et al. · Journal of Medicinal Chemistry · 1998 · 84 citations · Full text

Combinatorial Chemistry, Bioorganic Chemistry, Pharmacotherapy +17

Resistance to anthrapyrazoles and anthracyclines in multidrug-resistant P388 murine leukemia cells: reversal by calcium blockers and calmodulin antagonists.

Wayne D. Klohs, Randall W. Steinkampf, Martha J. Havlick et al. · PubMed · 1986 · 68 citations

Antibiotic Adjuvant, P388 Cells, Pharmacotherapy +17

Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors

Cleo J. C. Connolly, James M. Hamby, Mel C. Schroeder et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 66 citations

Combinatorial Chemistry, Medicinal Chemistry, Novel Series +8