Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

Nicholas J. Laping, Eugene T. Grygielko, Anil Mathur, +10

Molecular Pharmacology

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong, +38

Journal of Medicinal Chemistry

Drug TargetImmunologyCell DeathPharmacotherapyInflammation +20

Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family

Sanjay Kumar, Peter McDonnell, Ruth Lehr, +8

Journal of Biological Chemistry

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

James F. Callahan, Joelle L. Burgess, James A. Fornwald, +10

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyCell GrowthTumor BiologyGrowth Factor Beta1 +16

DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Philip A. Harris, Bryan W. King, Deepak Bandyopadhyay, +29

Journal of Medicinal Chemistry

Drug TargetImmunologyKinase InhibitorsMolecular BiologyCell Death +15

INTERLEUKIN-1F7B (IL-1H4/IL-1F7) IS PROCESSED BY CASPASE-1 AND MATURE IL-1F7B BINDS TO THE IL-18 RECEPTOR BUT DOES NOT INDUCE IFN-γ PRODUCTION

Sanjay Kumar, Charles R. Hanning, Michael Brigham‐Burke, +10

Cytokine

InflammationCytokineImmune Cell DevelopmentImmune RegulationImmunology +10

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

Philip A. Harris, Deepak Bandyopadhyay, Scott B. Berger, +22

ACS Medicinal Chemistry Letters

Pathologies AssociatedApoptosisImmunologyCell DeathMolecular Biology +22

Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

Jeffrey D. Carson, Glenn Van Aller, Ruth Lehr, +8

Biochemical Journal

Signal TransductionSignaling PathwayBiochemistryClass Ia Pi3ksNatural Sciences +10

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

Lusong Luo, Cynthia A. Parrish, Neysa Nevins, +17

Nature Chemical Biology

Protein FunctionSignal TransductionBiochemistryNatural SciencesAtp-competitive Inhibitors +9

The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA

Claus Spitzfaden, Neville Nicholson, Jo J. Jones, +5

Journal of Molecular Biology

Ribonuclease P ProteinNatural SciencesUnique Binding SiteRna Structure PredictionRna Biology +7