Jiacheng Wei

Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy

Duan Ni, Jiacheng Wei, Xinheng He et al. · Chemical Science · 2020 · 132 citations · Full text

Pharmacy, Biology, Molecular Biology +16

Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

Shaoyong Lu, Ying-Yi Chen, Jiacheng Wei et al. · Acta Pharmaceutica Sinica B · 2020 · 89 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells

Qiufen Zhang, Yingyi Chen, Duan Ni et al. · Acta Pharmaceutica Sinica B · 2021 · 70 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

ASD2023: towards the integrating landscapes of allosteric knowledgebase

Jixiao He, Xinyi Liu, Chunhao Zhu et al. · Nucleic Acids Research · 2023 · 53 citations · Full text

Life Sciences, Biochemistry, Bioinformatics +13

Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D₃ in colorectal cancer

Jialin Shang, Zhehui Zhu, Ying‐Yi Chen et al. · Theranostics · 2020 · 49 citations · Full text

Medicine, Oncology, Pharmacology +17