Christian G. Peace

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Marah C. Runtsch, Stefano Angiari, Alexander Hooftman et al. · Cell Metabolism · 2022 · 318 citations

Life Sciences, Cell Biology, Immunology +14

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Alexander Hooftman, Christian G. Peace, Dylan G. Ryan et al. · Nature · 2023 · 224 citations · Full text

Life Sciences, Immunology, Molecular Biology +13

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Tristram A.J. Ryan, Alexander Hooftman, Aisling M. Rehill et al. · Nature Communications · 2023 · 64 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase

Shane M. O’Carroll, Christian G. Peace, Juliana E. Toller-Kawahisa et al. · Nature Metabolism · 2024 · 49 citations · Full text

Life Sciences, Immunology, Molecular Biology +11