Douglas McCloskey

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

Caroline A. Lewis, Seth J. Parker, Brian P. Fiske et al. · Molecular Cell · 2014 · 574 citations · Full text

Energy Metabolism, Biochemistry, Mitochondrial Function +12

A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action

Jason H. Yang, Sarah N. Wright, Meagan Hamblin et al. · Cell · 2019 · 321 citations · Full text

Antimicrobial Susceptibility, Machine Learning, Antibiotics +8

Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function

Jason H. Yang, Prerna Bhargava, Douglas McCloskey et al. · Cell Host & Microbe · 2017 · 257 citations · Full text

Inflammation, Dysbiosis, Antibiotics +11

Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution

José Utrilla, Edward J. O’Brien, Ke Chen et al. · Cell Systems · 2016 · 125 citations · Full text

Biology, Pattern Formation, Evolution Strategy +13

AMPD2 Regulates GTP Synthesis and Is Mutated in a Potentially Treatable Neurodegenerative Brainstem Disorder

Naiara Akizu, Vincent Cantagrel, Jana Schroth et al. · Cell · 2013 · 113 citations · Full text

Is Mutated, Neurodegenerative Diseases, Neurophysiology +8