Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

Angelika Bierhaus, Thomas Fleming, Stoyan Stoyanov, +30

Nature Medicine

NeurophysiologyPain MedicineMedicineDiabetesDiabetic Neuropathy +11

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

Maija Dambrova, Gustavs Latkovskis, Janis Kuka, +6

Experimental and Clinical Endocrinology & Diabetes

Worldwide inertia to the use of cardiorenal protective glucose-lowering drugs (SGLT2i and GLP-1 RA) in high-risk patients with type 2 diabetes

Guntram Schernthaner, Naim Shehadeh, Anna Bazarova, +13

Cardiovascular Diabetology

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Ilze Elbere, Ineta Kalniņa, Ivars Silamiķelis, +8

PLoS ONE

Acute anti‐hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study

Elīna Makarova, Paweł Górnaś, Ilze Konrāde, +6

Journal of the Science of Food and Agriculture

Meldonium decreases the diet‐increased plasma levels of trimethylamine N‐oxide, a metabolite associated with atherosclerosis

Maija Dambrova, Elina Skapare‐Makarova, Ilze Konrāde, +6

The Journal of Clinical Pharmacology

Metabolic SyndromeCardiovascular DiseaseMedicineLipid PeroxidationPhysiology +10

SDF-1 Genotype Influences Insulin-Dependent Mobilization of Adult Progenitor Cells in Type 2 Diabetes

Per M. Humpert, Renate Neuwirth, Marco Johannes Battista, +8

Diabetes Care

ImmunologyInsulin-dependent MobilizationInsulin SignalingRegenerative MedicineMetabolic Syndrome +20

Locally Applied Mononuclear Bone Marrow Cells Restore Angiogenesis and Promote Wound Healing in a Type 2 Diabetic Patient

Per M. Humpert, U. Bärtsch, Ilze Konrāde, +5

Experimental and Clinical Endocrinology & Diabetes

Cell TherapyAdult Stem CellSurgeryBiomedical EngineeringPromote Wound Healing +17

Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients

Ilze Elbere, Ivars Silamiķelis, Ilze Izabella Dindune, +9

PLoS ONE

Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients

Elina Skapare, Ilze Konrāde, Edgars Liepinsh, +6

Journal of Diabetes and its Complications

Type 1MedicineDiabetesPhysiologyDiabetic Neuropathy +7