Michael Melnick

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

Matthew F. Brown, Usa Reilly, J. A. Abramite et al. · Journal of Medicinal Chemistry · 2011 · 98 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme^,

P.W. Bilder, Sandra Lightle, Graeme Bainbridge et al. · Biochemistry · 2006 · 87 citations

Life Sciences, Biochemistry, Microbiology +12

Protein structure-based design of potent orally bioavailable, nonpeptide inhibitors of human immunodeficiency virus protease.

Siegfried Reich, Michael Melnick, Jay F. Davies et al. · Proceedings of the National Academy of Sciences · 1995 · 51 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Structure of a small‐molecule inhibitor complexed with GlmU from <i>Haemophilus influenzae</i> reveals an allosteric binding site

Igor Mochalkin, Sandra Lightle, Lakshmi Narasimhan et al. · Protein Science · 2008 · 50 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +15

Structure-Based Design and Synthesis of Substituted 2-Butanols as Nonpeptidic Inhibitors of HIV Protease:  Secondary Amide Series

Siegfried Reich, Michael Melnick, Mark J. Pino et al. · Journal of Medicinal Chemistry · 1996 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17