Mark J. Pino

Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis

Siegfried Reich, Mary Ann M. Fuhry, Dzuy Nguyen et al. · Journal of Medicinal Chemistry · 1992 · 61 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Protein structure-based design of potent orally bioavailable, nonpeptide inhibitors of human immunodeficiency virus protease.

Siegfried Reich, Michael Melnick, Jay F. Davies et al. · Proceedings of the National Academy of Sciences · 1995 · 51 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Structure-Based Design and Synthesis of Substituted 2-Butanols as Nonpeptidic Inhibitors of HIV Protease:  Secondary Amide Series

Siegfried Reich, Michael Melnick, Mark J. Pino et al. · Journal of Medicinal Chemistry · 1996 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-based drug design of nonpeptidic P2 substituents for HIV-1 protease inhibitors

Vincent J. Kalish, John H. Tatlock, Jay F. Davies et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 25 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16