Jonathan D. Macdonald

Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL^pro)

Sang Hoon Han, Christopher M. Goins, T. Arya et al. · Journal of Medicinal Chemistry · 2021 · 135 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

Erin R. Aho, Jing Wang, Rocco D. Gogliotti et al. · Cell Reports · 2019 · 123 citations · Full text

Life Sciences, Molecular Biology, Oncology +10

Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design

Selena Chacón Simon, Feng Wang, Lance R. Thomas et al. · Journal of Medicinal Chemistry · 2020 · 73 citations · Full text

Medicine, Molecular Biology, Oncology +15

Discovery of Potent 2-Aryl-6,7-dihydro-5 <i>H</i> -pyrrolo[1,2- <i>a</i> ]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Feng Wang, Kyu Ok Jeon, James M. Salovich et al. · Journal of Medicinal Chemistry · 2018 · 70 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction

Jonathan D. Macdonald, Selena Chacón Simon, Changho Han et al. · Journal of Medicinal Chemistry · 2019 · 64 citations · Full text

Medicine, Medicinal Chemistry, Oncology +15