Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL^pro)

Sang Hoon Han, Christopher M. Goins, T. Arya, +16

Journal of Medicinal Chemistry

Thermal and Photoinduced Copper-Promoted C–Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2<i>H</i>)-ones and Evaluation against <i>Mycobacterium tuberculosis</i>

Sandeep Thanna, Christopher M. Goins, Susan E. Knudson, +3

The Journal of Organic Chemistry

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

Kelly Mitchell, Samuel A. Sprowls, Sonali Arora, +22

Genes & Development

Exploitable TargetCancer BiologyGliomaTumor BiologyGbm Cscs +18

Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis

Sandeep Thanna, Susan E. Knudson, Anna E. Grzegorzewicz, +6

Organic & Biomolecular Chemistry

Exploring Covalent Allosteric Inhibition of Antigen 85C from <i>Mycobacterium tuberculosis</i> by Ebselen Derivatives

Christopher M. Goins, Steven Dajnowicz, Sandeep Thanna, +3

ACS Infectious Diseases

Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential <i>Mycobacterium tuberculosis</i> Lipid Esterases

Christopher M. Goins, Thanuja D. Sudasinghe, Xiaofan Liu, +3

Biochemistry

Lipid AnalysisBiochemistryLipid EsterasesNatural SciencesBiocatalysis +10

Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation

Jianneng Li, Michael Berk, Mohammad Alyamani, +8

Science Translational Medicine

Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis

Christopher M. Goins, Steven Dajnowicz, Micholas Dean Smith, +2

Journal of Biological Chemistry

BiotransformationBiochemistryNatural SciencesBiocatalysisMycobacterium Tuberculosis +6

BMX controls 3βHSD1 and sex steroid biosynthesis in cancer

Xiuxiu Li, Michael Berk, Christopher M. Goins, +10

Journal of Clinical Investigation

Androgen ReceptorBiochemistryMedicineHormonal ReceptorSex Steroid Biosynthesis +12

Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication

Taryn M. Serman, Cindy Chiang, Guanqun Liu, +10

Cell Host & Microbe

Virus StructureViral ReplicationMolecular VirologyBiochemistryNatural Sciences +10