Novel Trisubstituted Benzimidazoles, Targeting <i>Mtb</i> FtsZ, as a New Class of Antitubercular Agents

Kunal Kumar, Divya Awasthi, Seung-Yub Lee, +6

Journal of Medicinal Chemistry

Pharmaceutical ScienceAntitubercular AgentsPharmacotherapyAntimicrobial ChemotherapyPharmaceutical Chemistry +15

Slow-Onset Inhibition of the FabI Enoyl Reductase from <i>Francisella tularensis</i>: Residence Time and <i>in Vivo</i> Activity

Hao Lu, Kathleen England, Christopher am Ende, +10

ACS Chemical Biology

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: Novel antibacterial agents against Mycobacterium tuberculosis

Xiaokai Li, Nina Liu, Huaning Zhang, +3

Bioorganic & Medicinal Chemistry Letters

Novel Antibacterial AgentsAntimicrobial Drug DiscoveryPulmonary TuberculosisMedicineMycobacterium Tuberculosis +9

SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of <i>Mtb</i> FtsZ for the Development of Novel Antitubercular Agents

Divya Awasthi, Kunal Kumar, Susan E. Knudson, +2

Journal of Medicinal Chemistry

Lead CompoundsAntibacterial ActivityTrisubstituted BenzimidazolesLead IdentificationPharmacotherapy +19

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors

Christopher W. am Ende, Susan E. Knudson, Nina Liu, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryAntifungal AgentAntibioticsMedicine +9

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

J. Schiebel, Andrew Chang, Sonam Shah, +15

Journal of Biological Chemistry

Medicinal ChemistryAntimicrobial SusceptibilityBiochemistryAntibioticsRational Design +10

Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents

Bora Park, Divya Awasthi, Soumya R. Chowdhury, +5

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryEngineeringMedicineDrug Discovery +7

Time‐Dependent Diaryl Ether Inhibitors of InhA: Structure–Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

Pan Pan, Susan E. Knudson, Gopal R. Bommineni, +7

ChemMedChem

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors

Lauren A. Spagnuolo, Sandra Eltschkner, Weixuan Yu, +13

Journal of the American Chemical Society

Thermal and Photoinduced Copper-Promoted C–Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2<i>H</i>)-ones and Evaluation against <i>Mycobacterium tuberculosis</i>

Sandeep Thanna, Christopher M. Goins, Susan E. Knudson, +3

The Journal of Organic Chemistry