Talat Rahmati

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski et al. · Nature Cell Biology · 2000 · 520 citations

Life Sciences, Biochemistry, Medicinal Chemistry +13

Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

Michael S. Wolfe, Weiming Xia, Chad L. Moore et al. · Biochemistry · 1999 · 289 citations

Life Sciences, Biochemistry, Pharmacology +17

The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation

W. Taylor Kimberly, Weiming Xia, Talat Rahmati et al. · Journal of Biological Chemistry · 2000 · 256 citations · Full text

Life Sciences, Biochemistry, Neuroscience +11

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation

Weiming Xia, William J. Ray, Beth L. Ostaszewski et al. · Proceedings of the National Academy of Sciences · 2000 · 133 citations

Life Sciences, Cell Biology, Molecular Biology +13

FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage Complex

Weiming Xia, Beth L. Ostaszewski, W. Taylor Kimberly et al. · Neurobiology of Disease · 2000 · 51 citations · Full text

Life Sciences, Biochemistry, Neuroscience +15