Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Louis Vermeulen, Felipe de Sousa e Melo, Maartje van der Heijden, +12

Nature Cell Biology

OncologyMedicineStem CellsBiological MicroenvironmentsColorectal Cancer +8

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

Louis Vermeulen, Matilde Todaro, F. de Sousa Mello, +6

Proceedings of the National Academy of Sciences

Cell SpecializationCancer BiologyTumor BiologyTumor HeterogeneitySingle Cell Sequencing +16

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

Judith M. Müller, Oscar Krijgsman, Jennifer Tsoi, +16

Nature Communications

Tumor BiologyOncologyMedicineMelanomaLow Mitf/axl Ratio +8

The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Kristel Kemper, Martin R. Sprick, Martijn de Bree, +8

Cancer Research

ImmunologyCd133 ProteinCancer BiologyTumor BiologyAc133 Epitope +14

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

Kristel Kemper, Pramudita R. Prasetyanti, Wim de Lau, +3

Stem Cells

CopywriteR: DNA copy number detection from off-target sequence data

Thomas Kuilman, Arno Velds, Kristel Kemper, +14

Genome Biology

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors

Julia Boshuizen, Louise A. Koopman, Oscar Krijgsman, +17

Nature Medicine

Melanoma HeterogeneityAxl Antibody-drug ConjugateDrug TargetingMedicineMelanoma +9

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch

Xiangjun Kong, Thomas Kuilman, Aida Shahrabi, +8

Nature

OncologyAddictionMedicinePharmacologyCancer Drug Addiction +6

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yong Yu, Kolja Schleich, Bin Yue, +22

Cancer Cell

PhotocarcinogenesisMelanomaMolecular BiologyCellular SenescenceTumor Suppressor +6

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

Roelof J.C. Kluin, Kristel Kemper, Thomas Kuilman, +14

BMC Bioinformatics