Martin R. Sprick

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Louis Vermeulen, Felipe de Sousa e Melo, Maartje van der Heijden et al. · Nature Cell Biology · 2010 · 1.8K citations

Oncology, Medicine, Stem Cells +10

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

Irène Baccelli, Andreas Schneeweiß, Sabine Riethdorf et al. · Nature Biotechnology · 2013 · 1K citations

Tumor Biology, Xenograft Assay, Breast Oncology +10

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

Martin R. Sprick, Markus Weigand, Eva Rieser et al. · Immunity · 2000 · 794 citations · Full text

Trail Receptors 1, Signal Transduction, Apoptosis Mediated +11

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

Louis Vermeulen, Matilde Todaro, F. de Sousa Mello et al. · Proceedings of the National Academy of Sciences · 2008 · 717 citations · Full text

Cell Specialization, Cancer Biology, Tumor Biology +18

The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Kristel Kemper, Martin R. Sprick, Martijn de Bree et al. · Cancer Research · 2010 · 368 citations · Full text

Immunology, Cd133 Protein, Cancer Biology +16