Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements

Tomohiro Yoshikawa, Hitoshi Shimano, Naoya Yahagi, +15

Journal of Biological Chemistry

Promoter ActivityPufa SuppressionFatty Liver DiseaseLiver X ReceptorFatty Acids +14

Polyunsaturated Fatty Acids Ameliorate Hepatic Steatosis in Obese Mice by Srebp–1 Suppression

Motohiro Sekiya, Naoya Yahagi, Takashi Matsuzaka, +7

Hepatology

SREBPs suppress IRS-2-mediated insulin signalling in the liver

Tomohiro Ide, Hitoshi Shimano, Naoya Yahagi, +10

Nature Cell Biology

Metabolic SyndromeSignal TransductionHepatologyBiochemistryLiver Physiology +6

Cross-Talk between Peroxisome Proliferator-Activated Receptor (PPAR) α and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. II. LXRs Suppress Lipid Degradation Gene Promoters through Inhibition of PPAR Signaling

Tomohiro Ide, Hitoshi Shimano, Tomohiro Yoshikawa, +14

Molecular Endocrinology

Gel Shift AssaysPeroxisome Proliferator-activated ReceptorLiver X ReceptorOxidative StressMetabolic Syndrome +14

Antiobesity Effect of Eicosapentaenoic Acid in High-Fat/High-Sucrose Diet–Induced Obesity

Ayumi Sato, Hiroyuki Kawano, Tatsuto Notsu, +6

Diabetes

SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes

Takashi Yamamoto, Hitoshi Shimano, Yoshimi Nakagawa, +10

Journal of Biological Chemistry

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

Toyonori Kato, Hitoshi Shimano, Takashi Yamamoto, +14

Diabetes

Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages

Hirohito Sone, Hitoshi Shimano, Miao Shu, +13

Biochemical and Biophysical Research Communications

InflammationCytokineSignal TransductionMolecular PathwayCellular Biochemistry +5

Lipid Synthetic Transcription Factor SREBP-1a Activates p21^WAF1/CIP1, a Universal Cyclin-Dependent Kinase Inhibitor

Noriyuki Inoue, Hitoshi Shimano, Masanori Nakakuki, +10

Molecular and Cellular Biology

P21 MrnaMolecular BiologyLipid MovementTranscriptional RegulationSignaling Pathway +14

Purification and some properties of delta-aminolevulinate synthase from the rat liver cytosol fraction and immunochemical identity of the cytosolic enzyme and the mitochondrial enzyme.

Masanori Nakakuki, Kiyoshi Yamauchi, Norio Hayashi, +1

Journal of Biological Chemistry

Cytosolic EnzymeCellular EnzymologyBiochemistryMitochondrial FunctionNatural Sciences +7