Tatsushi Yokogawa

Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models

Nozomu Tanaka, Kazuki Sakamoto, Hiroyuki Okabe et al. · Oncology Reports · 2014 · 142 citations · Full text

Medicine, Oncology, Pharmacology +13

An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA

Tomohiro Emura, Fumio Nakagawa, Akio Fujioka et al. · International Journal of Molecular Medicine · 2004 · 85 citations

Medicine, Oncology, Pharmacology +16

Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2′-deoxy-5-fluorouridine into DNA

Kazuki Sakamoto, Tatsushi Yokogawa, Hiroyuki Ueno et al. · International Journal of Oncology · 2015 · 57 citations · Full text

Medicine, Oncology, Pharmacology +13

1,2,3-Triazole-Containing Uracil Derivatives with Excellent Pharmacokinetics as a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors

Hitoshi Miyakoshi, Seiji Miyahara, Tatsushi Yokogawa et al. · Journal of Medicinal Chemistry · 2012 · 56 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells

Tatsushi Yokogawa, Wakako Yano, Sayaka Tsukioka et al. · Cancer Science · 2020 · 41 citations · Full text

Life Sciences, Molecular Biology, Oncology +17