Akio Fujioka

Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models

Nozomu Tanaka, Kazuki Sakamoto, Hiroyuki Okabe et al. · Oncology Reports · 2014 · 140 citations · Full text

Antitumor Activity, Medicine, Tumor Growth +14

An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA

Tomohiro Emura, Fumio Nakagawa, Akio Fujioka et al. · International Journal of Molecular Medicine · 2004 · 85 citations

Pharmaceutical Science, Chemical Biology, Culture Medium +21

Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo

Tomohiro Emura, Norihiko Suzuki, Akio Fujioka et al. · International Journal of Oncology · 2005 · 74 citations

Thymidine Analog, Antitumor Activity, Chemoprevention Strategy +16

1,2,3-Triazole-Containing Uracil Derivatives with Excellent Pharmacokinetics as a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors

Hitoshi Miyakoshi, Seiji Miyahara, Tatsushi Yokogawa et al. · Journal of Medicinal Chemistry · 2012 · 55 citations · Full text

Human Dutpase Inhibitors, Pharmaceutical Science, Pharmacotherapy +19

Relationship between Protein Levels and Gene Expression of Dihydropyrimidine Dehydrogenase in Human Tumor Cells during Growth in Culture and in Nude Mice

Teiji Takechi, Hiroyuki Okabe, Akio Fujioka et al. · Japanese Journal of Cancer Research · 1998 · 44 citations · Full text