Hitoshi Miyakoshi

1,2,3-Triazole-Containing Uracil Derivatives with Excellent Pharmacokinetics as a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors

Hitoshi Miyakoshi, Seiji Miyahara, Tatsushi Yokogawa et al. · Journal of Medicinal Chemistry · 2012 · 55 citations · Full text

Human Dutpase Inhibitors, Pharmaceutical Science, Pharmacotherapy +19

Discovery of a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors Remarkably Enhancing the Antitumor Activity of Thymidylate Synthase Inhibitors

Seiji Miyahara, Hitoshi Miyakoshi, Tatsushi Yokogawa et al. · Journal of Medicinal Chemistry · 2012 · 32 citations · Full text

Human Dutpase Inhibitors, Antitumor Activity, Chemoprevention Strategy +21

TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy

Wakako Yano, Tatsushi Yokogawa, Takeshi Wakasa et al. · Molecular Cancer Therapeutics · 2018 · 29 citations

Discovery of Highly Potent Human Deoxyuridine Triphosphatase Inhibitors Based on the Conformation Restriction Strategy

Seiji Miyahara, Hitoshi Miyakoshi, Tatsushi Yokogawa et al. · Journal of Medicinal Chemistry · 2012 · 24 citations · Full text

Synthesis and Discovery of<i>N</i>-Carbonylpyrrolidine- or<i>N</i>-Sulfonylpyrrolidine-Containing Uracil Derivatives as Potent Human Deoxyuridine Triphosphatase Inhibitors

Hitoshi Miyakoshi, Seiji Miyahara, Tatsushi Yokogawa et al. · Journal of Medicinal Chemistry · 2012 · 15 citations · Full text