Wakako Yano

1,2,3-Triazole-Containing Uracil Derivatives with Excellent Pharmacokinetics as a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors

Hitoshi Miyakoshi, Seiji Miyahara, Tatsushi Yokogawa et al. · Journal of Medicinal Chemistry · 2012 · 55 citations · Full text

Human Dutpase Inhibitors, Pharmaceutical Science, Pharmacotherapy +19

dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells

Tatsushi Yokogawa, Wakako Yano, Sayaka Tsukioka et al. · Cancer Science · 2020 · 38 citations · Full text

Tumor Biology, Genome Instability, Dna Damage +10

Discovery of a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors Remarkably Enhancing the Antitumor Activity of Thymidylate Synthase Inhibitors

Seiji Miyahara, Hitoshi Miyakoshi, Tatsushi Yokogawa et al. · Journal of Medicinal Chemistry · 2012 · 32 citations · Full text

Human Dutpase Inhibitors, Antitumor Activity, Chemoprevention Strategy +21

Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations

Isao Miyazaki, Igor Odintsov, Keiji Ishida et al. · Nature Cancer · 2023 · 30 citations · Full text

TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy

Wakako Yano, Tatsushi Yokogawa, Takeshi Wakasa et al. · Molecular Cancer Therapeutics · 2018 · 29 citations