Troy Smith

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

Julien P. N. Papillon, Katsumasa Nakajima, Christopher D. Adair et al. · Journal of Medicinal Chemistry · 2018 · 225 citations · Full text

Brahma Homolog, Molecular Biology, Cancer Biology +19

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 207 citations · Full text

<i>N</i>-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2<i>E</i>)-<i>N</i>-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1<i>H</i>-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Stacy Remiszewski, Lidia Sambucetti, Kenneth W. Bair et al. · Journal of Medicinal Chemistry · 2003 · 129 citations · Full text

Pathology, Pharmacotherapy, Pharmaceutical Chemistry +17

Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor

Michael D. Shultz, Atwood K. Cheung, C.A. Kirby et al. · Journal of Medicinal Chemistry · 2013 · 122 citations · Full text

Drug Target, Selective Tankyrase Inhibitors, Pharmacotherapy +18

4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6

Young Shin Cho, Maria Borland, Christopher T. Brain et al. · Journal of Medicinal Chemistry · 2010 · 91 citations · Full text

Cyclin-dependent Kinase 4/6, Combinatorial Chemistry, Medicinal Chemistry +15