Stephen J. Tam

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

Stephen J. Tam, Ron Geller, Christoph Spiess et al. · Nature Cell Biology · 2006 · 310 citations · Full text

Molecular Pharmacology, Biochemistry, Natural Sciences +10

Protein quality control: chaperones culling corrupt conformations

Amie J. McClellan, Stephen J. Tam, Daniel Kaganovich et al. · Nature Cell Biology · 2005 · 278 citations

Protein Chemistry, Protein Quality Control, Protein Assembly +7

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

Stephen J. Tam, Christoph Spiess, William Auyeung et al. · Nature Structural & Molecular Biology · 2009 · 247 citations · Full text

Protein Function, Protein Assembly, Protein Folding +13

Death Receptors DR6 and TROY Regulate Brain Vascular Development

Stephen J. Tam, David Richmond, Joshua S. Kaminker et al. · Developmental Cell · 2012 · 138 citations · Full text

Endothelial Dysfunction, Cell Death, Vascular Biology +6

Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

Jeffrey N. Higaki, Avijit Chakrabartty, Natalie J. Galant et al. · Amyloid · 2016 · 85 citations · Full text