Christoph Spiess

A Temperature-Dependent Switch from Chaperone to Protease in a Widely Conserved Heat Shock Protein

Christoph Spiess, Alexandra Beil, Michael Ehrmann · Cell · 1999 · 757 citations · Full text

Protein Function, Biochemistry, Protein Assembly +9

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

Megan Lo, Hok Seon Kim, Raymond K. Tong et al. · Journal of Biological Chemistry · 2017 · 315 citations · Full text

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

Stephen J. Tam, Ron Geller, Christoph Spiess et al. · Nature Cell Biology · 2006 · 310 citations · Full text

Molecular Pharmacology, Biochemistry, Natural Sciences +10

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

Stephen J. Tam, Christoph Spiess, William Auyeung et al. · Nature Structural & Molecular Biology · 2009 · 247 citations · Full text

Protein Function, Protein Assembly, Protein Folding +13

Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies

Christoph Spiess, Mark Merchant, Arthur Huang et al. · Nature Biotechnology · 2013 · 197 citations

Distinct Half-antibodies, Immunology, Bacteriology +10