Jeffrey N. Higaki

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

Dietmar Seiffert, Jodi D. Bradley, Cynthia M. Rominger et al. · Journal of Biological Chemistry · 2000 · 301 citations · Full text

Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS

Theo Hagg, Diana Quon, Jeffrey N. Higaki et al. · Neuron · 1992 · 215 citations

Brain-immune Interaction, Neuroscience, Neurology +7

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

Jeffrey N. Higaki, Diana Quon, Ziyang Zhong et al. · Neuron · 1995 · 146 citations · Full text

Biochemistry, Protein Folding, Medicine +9

Introduction of a cysteine protease active site into trypsin

Jeffrey N. Higaki, Luke B. Evnin, Charles S. Craik · Biochemistry · 1989 · 94 citations

A Possible Role for Cathepsins D, E, and B in the Processing of β‐amyloid Precursor Protein in Alzheimer's Disease

Elaine A. Mackay, Anne Ehrhard, Marc Moniatte et al. · European Journal of Biochemistry · 1997 · 90 citations