Brian Samas

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of a Clinical Candidate from the Structurally Unique Dioxa-bicyclo[3.2.1]octane Class of Sodium-Dependent Glucose Cotransporter 2 Inhibitors

Vincent Mascitti, Tristan S. Maurer, Ralph P. Robinson et al. · Journal of Medicinal Chemistry · 2011 · 134 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Brian S. Gerstenberger, John D. Trzupek, C. Tallant et al. · Journal of Medicinal Chemistry · 2016 · 110 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

An intravenous formulation decision tree for discovery compound formulation development

Yung-Chi Lee, Philip Zocharski, Brian Samas · International Journal of Pharmaceutics · 2003 · 101 citations

Pharmacy, Pharmaceutics, Pharmacology +14

A Highly Enantioselective Allylic Amination Reaction Using a Commercially Available Chiral Rhodium Catalyst: Resolution of Racemic Allylic Carbonates

Derek Vrieze, Garrett Hoge, Perrine Z. Hoerter et al. · Organic Letters · 2009 · 73 citations

Natural Sciences, Chemistry, Catalysis +12