Ayman El‐Kattan

Delineating the role of cooperativity in the design of potent PROTACs for BTK

Adelajda Zorba, Chuong Nguyen, Yingrong Xu et al. · Proceedings of the National Academy of Sciences · 2018 · 423 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +15

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

Manthena V. S. Varma, R. Scott Obach, Charles J. Rotter et al. · Journal of Medicinal Chemistry · 2010 · 325 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Development of a new permeability assay using low‐efflux MDCKII cells

Li Di, Carrie Whitney‐Pickett, John P. Umland et al. · Journal of Pharmaceutical Sciences · 2011 · 317 citations

Pharmacy, Cell Biology, Cell Biophysics +10

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

Manthena V. S. Varma, Stefanus J. Steyn, Charlotte Allerton et al. · Pharmaceutical Research · 2015 · 311 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data

Hannah M. Jones, Hugh A. Barton, Yurong Lai et al. · Drug Metabolism and Disposition · 2012 · 242 citations

Pharmacy, Pharmacokinetics, Pharmacology +16