Expanding chemical biology of 2-oxoglutarate oxygenases

Christoph Loenarz, Christopher J. Schofield

Nature Chemical Biology

BiochemistryNatural SciencesEnzyme CatalysisChemical BiologyRedox Biology +1

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study

N. Burgess-Brown, Sujata Sharma, Frank Sobott, +3

Protein Expression and Purification

Multi-gene StudyFunctional GenomicsEngineeringProtein ExpressionGenetics +11

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

Patrick J. Pollard, Christoph Loenarz, David R. Mole, +4

Biochemical Journal

Histone ModificationsEpigenetic ChangeGeneticsRedox BiologyEpigenetics +17

The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, <i>Trichoplax adhaerens</i>

Christoph Loenarz, Mathew L. Coleman, Anna Boleininger, +4

EMBO Reports

BiologyRedox SignalingTranscriptional RegulationBiochemistryNatural Sciences +10

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

Rasheduzzaman Chowdhury, M.A. McDonough, Jasmin Mecinović, +5

Structure

Hypoxia-inducible FactorAldehyde DehydrogenaseOxygen-sensing Prolyl HydroxylasesBiochemistryRedox Regulator +8

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase

Christoph Loenarz, Wei Ge, Mathew L. Coleman, +5

Human Molecular Genetics

GeneticsMaternal HypoxiaMolecular BiologyGene CharacterizationMolecular Genetics +15

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

Lars Hillringhaus, Wyatt W. Yue, Nathan R. Rose, +7

Journal of Biological Chemistry

Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)

Armin Thalhammer, Zuzana Bencokova, Rachel L. Poole, +10

PLoS ONE

Direct TargetAlkbh GenesHypoxia-inducible Factor 1αMolecular BiologyAlkbh Proteins +15

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

Wei Ge, Alexander Wolf, Tianshu Feng, +29

Nature Chemical Biology

BiosynthesisCellular EnzymologyBiochemistryNatural SciencesProtein Biosynthesis +5

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

Christoph Loenarz, Rok Sekirnik, Armin Thalhammer, +9

Proceedings of the National Academy of Sciences