Patrick J. Pollard

Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations

Patrick J. Pollard, J.-J. Brière, Neyaz Alam et al. · Human Molecular Genetics · 2005 · 849 citations · Full text

Medicine, Genetics, Oncology +17

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Massimiliano Mazzone, Daniela Dettori, Rodrigo Leite de Oliveira et al. · Cell · 2009 · 812 citations · Full text

Medicine, Cancer Biology, Molecular Biology +17

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

Julie Adam, Emine Hatipoglu, Linda O′Flaherty et al. · Cancer Cell · 2011 · 578 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

David R. Mole, Christine Blancher, Richard R. Copley et al. · Journal of Biological Chemistry · 2009 · 550 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

Christian Frezza, Liang Zheng, Ori Folger et al. · Nature · 2011 · 535 citations

Life Sciences, Biochemistry, Cancer Biology +12