Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma

Tetsuhiro Chiba, Tomoko Saito, Kaori Yuki, +12

International Journal of Cancer

Histone ModificationsHistone H3Epigenetic ChangeMolecular BiologyPathology +19

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

Wakako Kuribayashi, Motohiko Oshima, Naoki Itokawa, +9

The Journal of Experimental Medicine

GeneticsAdult Stem CellEpigeneticsRegenerative MedicineStem Cell Mobilization +14

Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition

Ola Rizq, Naoya Mimura, Motohiko Oshima, +12

Clinical Cancer Research

Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners

Tetsuhiro Chiba, Eiichiro Suzuki, Kaori Yuki, +16

PLoS ONE

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Shuhei Koide, Motohiko Oshima, Keiyo Takubo, +16

Blood

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Naoki Itokawa, Motohiko Oshima, Shuhei Koide, +9

Nature Communications

Metformin, a Diabetes Drug, Eliminates Tumor-Initiating Hepatocellular Carcinoma Cells

Tomoko Saito, Tetsuhiro Chiba, Kaori Yuki, +13

PLoS ONE

Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation

Ryota Kurimoto, Shunichiro Iwasawa, Takahiro Ebata, +7

International Journal of Oncology

Tgf-β/fgf-2-driven Epithelial-to-mesenchymal TransitionImmunologyImmunoeditingMtor PathwaysCancer Biology +20

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy

Koichi Murakami, Daisuke Kurotaki, Wataru Kawase, +20

Cell Reports

O-linked N-acetylglucosamineMitophagyMitochondrial QualityCell DivisionStem Cell Mobilization +13

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies

Tomoyuki Tanaka, Yaeko Nakajima‐Takagi, Kazumasa Aoyama, +12

The Journal of Experimental Medicine