Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells

Ruiran Wei, Yueqin Zhao, Juan Wang, +9

International Journal of Biological Sciences

Ser ¹²⁹² Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

Zejuan Sheng, Shuo Zhang, Daisy Bustos, +22

Science Translational Medicine

Protein kinase C controls lysosome biogenesis independently of mTORC1

Yang Li, Meng Xu, Xiao Ding, +18

Nature Cell Biology

Lysosome BiogenesisSignal TransductionCell RegulationMedicineCell Biology +2

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Anthony A. Estrada, Xingrong Liu, Charles Baker‐Glenn, +36

Journal of Medicinal Chemistry

Small Molecule InhibitorsBroad Kinase SelectivityDrug TargetPharmaceutical ChemistryMedicinal Chemistry +17

Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis

Chia‐Lin Hsu, Wei‐Yu Lin, Dhaya Seshasayee, +20

Science

ImmunologyPathologyCell DeathCellular PhysiologyCell Autophagy +19

Design, Synthesis, and Evaluation of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles

Dongwei Kang, Zengjun Fang, Zhenyu Li, +11

Journal of Medicinal Chemistry

Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response

Harvey Wong, Edna F. Choo, Bruno Alicke, +8

Clinical Cancer Research

SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition

Jesse E. Hanson, Hank La, Emile G. Plise, +11

PLoS ONE

Synaptic TransmissionNeurotransmitterStructural PlasticitySocial SciencesHdac Inhibition +18

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

Lin Sun, Tianguang Huang, Alexej Dick, +9

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryMedicine4-Phenyl-1h-1,2,3-triazole Phenylalanine Derivatives +9

Fusarium solani, Tax-3, a new endophytic taxol-producing fungus from Taxus chinensis

Bai Wan Deng, Kai Hui Liu, Wen Qiang Chen, +2

World Journal of Microbiology and Biotechnology

BiologyFungal DiversityBiosynthesisEngineeringEndophyte Research +6