An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen, +32

Nature

Novel TherapyMedicineNew ApproachAnti-cancer AgentTumor Suppressor +7

Structure of ubiquitin refined at 1.8 Å resolution

Senadhi Vijay‐Kumar, Charles E. Bugg, William J. Cook

Journal of Molecular Biology

BiochemistryNatural SciencesProtein X-ray CrystallographyMolecular BiologyStructure Elucidation +1

Structure determination of the small ubiquitin-related modifier SUMO-1

Peter Bayer, Andreas Arndt, Susanne Metzger, +4

Journal of Molecular Biology

Structural BioinformaticsBiomolecular Structure PredictionStructure DeterminationMolecular BiologyStructural Biology

Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation.

Arthur L. Haas, J V Warms, Avram Hershko, +1

Journal of Biological Chemistry

Protein ChemistryProtein FunctionAldo-keto ReductaseCellular EnzymologyBiochemistry +13

The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis.

Arthur L. Haas, I A Rose

Journal of Biological Chemistry

Protein ChemistryBiochemistryEquilibrium AnalysisNatural SciencesEnzyme Catalysis +3

Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1

L. María Lois, Christopher D. Lima

The EMBO Journal

Molecular PhysiologySignal TransductionNatural SciencesGeneticsMolecular Biology +6

Functional heterogeneity of ubiquitin carrier proteins.

Cecile M. Pickart, I A Rose

Journal of Biological Chemistry

The Structure of the APPBP1-UBA3-NEDD8-ATP Complex Reveals the Basis for Selective Ubiquitin-like Protein Activation by an E1

Helen Walden, Michael Podgorski, Danny T. Huang, +5

Molecular Cell

Appbp1-uba3-nedd8-atp ComplexProtein FunctionNatural SciencesMedicineMolecular Biology +6

Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes

Imsang Lee, Hermann Schindelin

Cell

Protein ChemistryProtein FunctionBiochemistryProtein AssemblyNatural Sciences +6

Structural Basis for Recognition of Diubiquitins by NEMO

Yu-Chih Lo, Su‐Chang Lin, Carla C. Rospigliosi, +5

Molecular Cell

Molecular CharacterizationBioanalysisMolecular BiologyStructural BasisMolecular Recognition +2