An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation

A general framework for estimating the relative pathogenicity of human genetic variants

Martin Kircher, Daniela Witten, Preti Jain et al. · Nature Genetics · 2014 · 6.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly

Dietke Buck, Laurent Malivert, Régina de Chasseval et al. · Cell · 2006 · 702 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

Christophe Pannetier, Madeleine Cochet, Sylvie Darche et al. · Proceedings of the National Academy of Sciences · 1993 · 643 citations

Life Sciences, Immunology, Molecular Biology +17

DNA repair is limiting for haematopoietic stem cells during ageing

Anastasia Nijnik, Lisa Woodbine, Caterina Marchetti et al. · Nature · 2007 · 510 citations

Life Sciences, Cell Biology, Hematology +13

Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre

Riccardo Bennett-Lovsey, Alex Herbert, Michael J.E. Sternberg et al. · Proteins Structure Function and Bioinformatics · 2007 · 409 citations

Life Sciences, Bioinformatics, Biology +16